Translationale Kardiologie

Zelluläre Biophysik und Translationale Kardiologie
Research Unit for Cellular Biophysics and Translational Cardiology

A major focus of our group are molecular and spatial mechanisms of cardiac excitation-contraction coupling and changes in heart disease. In particular, we investigate calcium transport proteins in the context of native subcellular signaling nanodomains. An important example is the ryanodine receptor, an essential intracellular calcium release channel for heart and brain function. Ryanodine receptor dysfunction contributes to a spectrum of diseases including arrhythmias, heart failure, malignant hyperthermia, muscular dystrophy, and epilepsy. In electrically excitable cells like cardiac myocytes, ryanodine receptors are thought to contribute to point-like sources of intracellular calcium signals for highly localized control of subcellular signaling. In addition, ryanodine receptors form complex protein networks with sensory functions which may integrate stress signaling with calcium release. Current disease models predict that ryanodine receptor dysfunction contributes to cardiac arrhythmias and a loss of contractile function. Therefore, small drug compounds have been developed and are investigated for their potential to treat electrical or contractile cardiac dysfunction.

We employ a variety of research techniques including molecular biology, lipid bilayer single-channel measurements, cell biology, confocal and 2-photon microscopy, STED nanoscopy, patch-clamp, in vivo electrophysiology, and voltage imaging in intact tissue. Transgenic models of causative disease mutations or molecular targeting of signaling mechanisms are studied comprehensively from the molecule to organ levels. Much of our research is "translational" aiming to contribute to better understanding of the molecular basis of disease mechanisms. Additionally, novel diagnostic and therapeutic strategies are developed.

We collaborate with outstanding scientists nationally and internationally in major research programs. This includes the Collaborative Research Unit SFB 1002, the Clinical Research Unit KFO 155, and the large-scale FP7 consortium EUTrigTreat (coordinated by Prof. Lehnart). We work closely with the Biochemistry institutes (Prof. Schwappach), with the Biomedical Physics group of the Max-Planck Institute for Dynamics and Self-Organization (Prof. Luther, Prof. Bodenschatz), and with the Dept. of NanoBiophotonics of the Max-Planck Institute for Biophysical Chemistry (Prof. Hell). Together with other investigators of the Heart Research Center Goettingen we contribute to several projects of the National Genome Research Network (NGFN+) and the German Center for Cardiovascular Research (DZHK).

Ansprechpartner / Kontakt
Lehnart
Prof. Dr. med. Stephan E. Lehnart
Arbeitsgruppenleiter und SFB1002-Teilprojektleiter
Telefon:
0551-39-63630
E-Mail:
slehnart@med.uni-goettingen.de


             

Christiane Schulz
Sekretariat Prof. Lehnart
Telefon:
+49 (0)551 39 63631
Telefax:
+49 (0)551 39 63724
E-Mail:
cschulz@med.uni-goettingen.de
Ort:
4 B2 054.1
Telelift:
194
Sören Brandenburg
MD/PhD Student
Telefon:
+49 (0)551 39 63637
E-Mail:
soeren.brandenburg@med.uni-goettingen.de
Miroslav Dura Ph.D.
Telefon:
+49 (0)551 39 63640
Telefax:
+49 (0)551 39 63705
E-Mail:
miroslav.dura@med.uni-goettingen.de
Sarah Gockel
MD/PhD Student
Telefon:
+49 (0)551 39 12644
Telefax:
+49 (0)551 39 10650
E-Mail:
sarahgockel@gmx.de
Konstantin Gusev Ph.D.
Telefon:
+49 (0)551 39 12644
Telefax:
+49 (0)551 39 10650
E-Mail:
konstantin.gusev@med.uni-goettingen.de
Alex Johnston
PhD Student - IRTG 1816
Telefon:
+49 (0)551 39 12644
Telefax:
+49 (0)551 39 10650
E-Mail:
alex.johnston@med.uni-goettingen.de
Dr. rer. nat. Tobias Kohl
Telefon:
+49 (0)551 39 63640
Telefax:
+49 (0)551 39 63705
E-Mail:
tobias.kohl@med.uni-goettingen.de
Brigitte Korff
Technical Assistant
Telefon:
+49 (0)551 39 63642/63643
Telefax:
+49 (0)551 39 63710
E-Mail:
brigitte.korff@med.uni-goettingen.de
Jonas Peper
Telefon:
+49 (0)551 39 63637
Telefax:
+49 (0)551 39 63704
E-Mail:
jonas.peper@med.uni-goettingen.de
Birgit Schumann
Technical Assistant
Telefon:
+49 (0)551 39 63649/63644
Telefax:
+49 (0)551 39 63710
E-Mail:
birgit.schumann@med.uni-goettingen.de
Dr. rer. nat. Eva Wagner
Telefon:
+49 (0)551 39 63640
Telefax:
+49 (0)551 39 63705
E-Mail:
eva.wagner@med.uni-goettingen.de
Dr. rer. nat. Gunnar Weninger
Telefon:
+49 (0)551 39 63637
Telefax:
+49 (0)551 39 63704
E-Mail:
gunnar.weninger@med.uni-goettingen.de

Former members

Dipl.-Biol. Julia Hanni Steinbrecher
Dr. rer. nat. Silvio Weber
Arbeitsgruppenleiter Kardiale Sheddomik, Institut für Pharmakologie und Toxikologie, TU Dresden
Dr. Jan-Hendrik Streich
Novartis Pharma GmbH
Nour Raad
Assistenzärztin
Telefon:
0551-39-66328
Pieper:
919 - 2767
E-Mail:
nour.raad@med.uni-goettingen.de
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